Archaeology of Southern Mesoamerica comprises the second and third volumes in the Handbook of Middle American Indians, published in cooperation with the Middle American Research Institute of Tulane University under the general editorship of Robert Wauchope (1909–1979). The volume editor is Gordon R. Willey (1913–2002), Bowditch Professor of Mexican and Central American Archaeology and Ethnology at Harvard University.

Volumes Two and Three, with more than 700 illustrations, contain archaeological syntheses, followed by special articles on settlement patterns, architecture, funerary practices, ceramics, artifacts, sculpture, painting, figurines, jades, textiles, minor arts, calendars, hieroglyphic writing, and native societies at the time of the Spanish conquest of the Guatemala highlands, the southern Maya lowlands, the Pacific coast of Guatemala, Chiapas, the upper Grijalva basin, southern Veracruz, Tabasco, and Oaxaca.

The Handbook of Middle American Indians was assembled and edited at the Middle American Research Institute of Tulane University with the assistance of grants from the National Science Foundation and under the sponsorship of the National Research Council Committee on Latin American Anthropology.