Improvement in understanding of immune suppression mechanisms in the human body has revolutionized the way cancer is perceived and treated. The new book, Advances in Immunological Treatment of Cancer: Cellular Mechanism and Regulations, provides a clinically relevant overview of cancer immunology and immunotherapy. It explores the cutting-edge research behind cancer’s driving mechanism of immune suppression, as well as some cutting-edge therapeutic approaches to combating cancer. This book offers novel approaches to cancer therapy with a special emphasis on the emerging new principles of immune suppression that drive the disease. Further, the book explains the fundamental principles of immune suppression that are driving research in this area. It also shows that conventional chemotherapeutic drugs and molecularly targeted therapeutics can both have significant anti-tumor effects in animal models. The book comprehensively covers the immune escape as a critical trait in cancer and how specific combinations of immunotherapy and chemotherapy can be used to attack this trait.

The book focuses on the emerging new principles of immune suppression that drive cancer and provides radical new ideas for improving therapy by employing these principles. It also demonstrates the use and effectiveness of conventional chemotherapeutic drugs in eliminating tumors. The book provides an overview of immunoregulation via allogeneic stem cell transplantation and also discusses the various resistance mechanisms in cancer immunology. It offers new hope for survival via immunoediting and details the development of antigen and phenotypic plasticity molecules for cancer immunotherapy.

The authors discuss toll-like receptors and detail self-to-tumor immune interactions. Methods for reducing tumor growth and altering tumor immunogenicity are also discussed along with the many ways in which conventional chemotherapy can boost the immune system. The function of innate and adaptive immunity in immune vigilance is also explored.

This book is a must-read for researchers in basic, translational, and clinical cancer fields, as it provides a comprehensive overview of the immune escape process as a critical trait in cancer and how targeted combinations of immunotherapy and chemotherapy to combat this trait may significantly improve the treatment of cancer.