Description - Angiotensin II Receptors by Robert R. Ruffolo, Jr.
Presenting an in-depth overview of relevant information on angiotensin II receptors in humans, this volume emphasizes known and potential therapeutic applications. Beginning with the genes that encode these receptors and then extending to humans, the molecular biology of angiotensin II receptors is reviewed in detail, as are the biochemical effects mediated by angiotensin II receptors. This text details information regarding the cloning of angiotensin II receptors from a variety of species, discussing the molecular structure of the angiotensin II receptors, as well as heterogeneity in angiotensin II receptors at the molecular level. It also covers the biochemistry of the angiotensin II receptors, such as the heterogeneity in the angiotensin II receptors and the biochemical basis for their subclassification, and provides a thorough review of structure-activity relationships of angiotensin II receptor agonists and antagonists, including current nonpeptide angiotensin II receptor antagonists, which are of emerging clinical relevance for the treatment of a variety of cardiovascular diseases.
The text also reviews the pharmacological actions known to be mediated by angiotensin II receptors, and deals with drug and hormone receptors, as well as the pharmacology of angiotensin II receptor agonists and antagonists in humans.
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