Description - Cellular and Molecular Mechanisms of Hormonal Carcinogenesis by James Huff
The impact of gender and hormonal perturbations on the carcinogenesis process has now attracted the awareness of the general scientific and regulatory communities. Starting with the first report of induced mammary carcinoma in male mice by an exogenously administered female sex hormone, current research seems to implicate a hormonal influence or modulation for most induced cancers, both those involving endocrine and non-endocrine tissues. Gender, and thus hormonal, differences in response to environmental carcinogenesis are common, and cancer occurrences are often strikingly different between the sexes. This text explores these direct and indirect hormonal influences in mammalian carcinogenesis, especially in environmentally or xenobiotically associated cancers.
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