On Avenue B in the East Village, the Christodora is home to Milly and Jared, a privileged young couple with artistic ambitions. Their neighbor, Hector, a gay Puerto Rican man who was at one point celebrated for his work as an AIDS activist but has now descended into the throes of drug addiction, becomes connected to Milly and Jared's lives in ways none of them can anticipate. Meanwhile, Milly and Jared's adopted son Mateo grows to see the opportunity for both self-realization and oblivion offered by New York City. As the junkies and protestors of the 1980s give way to the hipsters of the 2000s and they in turn to the wealthy inhabitants of the glass towers of the 2020s, enormous changes rock the personal lives of Milly and Jared and the constellation of people around them.

Christodora is a panoramic novel that powerfully evokes the danger, chaos, and wonder of New York City--and the strange and moving ways in which its dwellers' lives can intersect.