In Diff'rent, The First Man, and Welded, egotistical characters have their illusions about love shaken by the force of other people's desires. All God's Chillun Got Wings depicts the web of racial hatreds and spiritual longings that surround the marriage of a black man and a white woman.

The Fountain tells of Ponce de Leon's search for the fountain of youth. Marco Millions satirizes American materialism by portraying Marco Polo as a hustling businessman blind to the riches of Eastern culture. Lazarus Laughed shows its Biblical hero preaching love, laughter, and the defeat of death.

The stoker Yank in The Hairy Ape, the architect Dion Anthony in The Great God Brown, and the minister's son Reuben Light in Dynamo all try to find a place for themselves in an increasingly soulless and mechanistic world. Yank believes that he "belongs" in his stokehold until a terrified heiress calls him a "filthy beast." His rage turns to despair as he encounters a brutally indifferent society onshore. The Great God Brown uses masks to depict the divided souls of its hero, his wife, and his alter ego, the successful businessman William Brown. Betrayed by his mother, Reuben Light forsakes the God of his father for the new electrical god of the dynamo but finds no escape from the sexual conflicts that O'Neill characteristically intertwines with his hero's religious doubts.

Strange Interlude follows its heroine Nina Leeds through nine acts and twenty-five years of passionate and painful involvement with three men. Inspired by contemporary psychology, the novels of James Joyce, and the soliloquies of the Elizabethan theater, O'Neill uses spoken asides to reveal the shifting flow of his character's inner thoughts. His most commercially successful play, it won him his third Pulitzer Prize.

Ephraim Cabot, the patriarchal farmer in Desire Under the Elms, believes in a God as hard as the stony ground he works. He takes as his third wife sensual Abbie Putnam, who covets both his land and his resentful son Eben, unleashing passions that move with stark inexorability toward their fulfillment. In Mourning Becomes Electra, murderous lusts and hatreds wreak havoc upon the proud Mannon family, leaving the survivors pursued not by the avenging Furies of Greek myth but by their own scourging consciences. Searching desperately for peace, they repeatedly confront the temptation to choose oblivion that will haunt many of O'Neill's last plays.

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