The early 1950s. Two brothers and a sister are marooned on a remote farm after their father's death. They are thrown into a state of panic when one of them makes a bid for freedom. Long-suppressed jealousies and resentments begin to seethe and fester. Thirty years later an unexpected visitor brings their feud to a climax.

Flesh and Blood completes Philip Osment's trilogy of Devon plays, following the highly acclaimed The Dearly Beloved (winner, 1993 Writers Guild Award) and What I Did in the Holidays (nominee 1995 Writers Guild Award).