From Vladimir to Vladimir is about the long and complicated relationship between Russia and Ukraine. It begins with Prince Vladimir of Kiev, who established the Kievan Rus' Empire (879-1240 CE), one that expanded and contracted over four centuries-longer than the United States has existed. The book ends with the Russian invasion of Ukraine in February of 2022.

Vicchio explores little-known or understood connections between Russia and Ukraine, including a period where three separate powers attempted to conquer Ukraine: the Mongols, the Polish Lithuanian Confederation, and the annexing of Ukraine by the Russians in 1792.

Other sections trace Russia and Ukraine in the two world wars, the relationship of Russia to Ukraine in the Soviet Era, and the fate of Ukraine since the dissolution of the Soviet Union on Christmas day, 1991.