Description - Fundamentals of Analytical Toxicology by Robert J. Flanagan
The analytical toxicologist may be required to detect, identify,
and in many cases measure a wide variety of compounds in samples
from almost any part of the body or in related materials such as
residues in syringes or in soil. This book gives principles and
practical information on the analysis of drugs and poisons in
biological specimens, particularly clinical and forensic specimens.
After providing some background information the book covers
aspects of sample collection, transport, storage and disposal, and
sample preparation. Analytical techniques - colour tests and
spectrophotometry, chromatography and electrophoresis, mass
spectrometry, and immunoassay ? are covered in depth, and a
chapter is devoted to the analysis of trace elements and toxic
metals. General aspects of method implementation/validation and
laboratory operation are detailed, as is the role of the toxicology
laboratory in validating and monitoring the performance of point of
care testing (POCT) devices. The book concludes with reviews of
xenobiotic absorption, distribution and metabolism,
pharmacokinetics, and general aspects of the interpretation of
analytical toxicology results.
A clearly written, practical, integrated approach to the basics
of analytical toxicology.
Focuses on analytical, statistical and pharmacokinetic
principles rather than detailed applications.
Assumes only a basic knowledge of analytical chemistry.
An accompanying website provides additional material and links
to related sites.
Written by an experienced team of authors,Fundamentals of
Analytical Toxicology is an invaluable resource for those
starting out in a career in analytical toxicology across a wide
range of disciplines including clinical and forensic science, food
safety, and pharmaceutical development.
Praise from the reviews:
?This is an ambitious effort to describe in detail the
many and varied aspects of the science of toxicological analysis.
The 17 chapters cover every foreseeable aspect, from specimen
collection through analytical techniques and quality control to
pharmacological principles and interpretation of results. The
authors bring together a great deal of experience in the field and
have succeeded admirably in achieving their goal: "to give
principles and practical information on the analysis of drugs,
poisons and other relevant analytes in biological specimens...".
The book is very readable and quite up-to-date, and contains many
illustrative figures, charts and tables. Both the student and the
practicing professional would do well to study this material
carefully, as there is something here for every conceivable level
of interest.? Review from Randall
Baselt
"This text comes highly recommended for any analytical
toxicology trainee." The Bulletin of the Royal College of
Pathologists
?Overall, this book provides a comprehensive, thorough,
clear, up to date and practical treatment of analytical toxicology
at a high standard. Understanding of the text is enhanced by
the use of many illustrations. Specifications, guidelines,
and methods are highlighted in grey background
?Boxes?. The many and up to date literature
references in each chapter demonstrate the authors? thorough
work and permit easy access to deeper information. Therefore
this book can be highly recommended as a valuable source of
knowledge in analytical toxicology both as an introduction and for
the advanced reader.? GTFCh Bulletin
?Toxichem + Krimtech?, May 2008 (translated,
original review in German)
?Many toxicologists will add this important reference
to their libraries because it competently fills a need
...? International Journal of Toxicology
?The book is very well illustrated, easy to understand
and pleasant to read, and contains a wealth of dedicated
information.? International Journal of Environmental
Analytical Chemistry
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Fundamentals of Analytical Toxicology: Clinical and Forensic
