Eager to interact with the newcomers, Dr. Stafford is quickly intrigued by their personal stories of struggles, courage, and determination. Soon though, everything is about to change on the island; major conflicts unfold, immigrants are exploited, and a riot takes place. Becoming entangled in a secret passionate relationship, Dr. Stafford witnesses President McKinley's assassination and a societal backlash against the rising tide of immigration. As he valiantly struggles to find emotional fulfillment, a series of events will lead to dramatic changes-both at Ellis Island and in his own life.

Based on actual events, Guardians of the Gate shares the intriguing tale of the people and provocative occurrences that occurred at Ellis Island during the 1890s and 1900s-through the eyes of a dedicated physician on a compelling quest for fulfillment.