Description - Human Drug Metabolism by Michael D. Coleman
Human Drug Metabolism, An Introduction, Second Edition
provides an accessible introduction to the subject and will be
particularly invaluable to those who already have some
understanding of the life sciences. Completely revised and updated
throughout, the new edition focuses only on essential chemical
detail and includes patient case histories to illustrate the
clinical consequences of changes in drug metabolism and its impact
on patient welfare.
After underlining the relationship between efficacy, toxicity
and drug concentration, the book then considers how metabolizing
systems operate and how they impact upon drug concentration, both
under drug pressure and during inhibition. Factors affecting drug
metabolism, such as genetic polymorphisms, age and diet are
discussed and how metabolism can lead to toxicity is explained. The
book concludes with the role of drug metabolism in the commercial
development of therapeutic agents as well as the pharmacology of
some illicit drugs.
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