Description - Peroxisome Proliferators by Mannfred A. Hollinger
Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial and regulatory areas of pharmacology and toxicology. This work brings together for the first time researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation with detailed tables on the 100 known peroxisome proliferators and studies of their hepatocarcinogenic capacity. Response of cytochrome P450's, UDP glucuronosyltransferases, epoxidehydrolases, glutathione S-transferase, DT-diaphorase and other enzymes are also covered.
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