As the chief of the new Cambridge Forensic Center in Massachusetts, a joint venture of the state and federal governments and MIT, Scarpetta is confronted with a case that could shut down her new facility and ruin her personally and professionally. A young man drops dead, apparently from a cardiac arrhythmia, eerily close to Scarpetta's new Cambridge home. But when his body is examined the next morning, there are stunning indications that he may have been alive when he was zipped inside a pouch and locked insider the Center's cooler. Various 3-D radiology scans reveal more shocking details about internal injuries unlike any Scarpetta has ever seen. These suggest the possibility of a conspiracy to cause mass casualties. She realizes that she is fighting a cunning and cruel enemy that is invisible as she races against time to discover who and why before more people die.

In Port Mortuary, Patricia Cornwell brings Scarpetta together with Marino, Benton, and Lucy in an intimate way that is reminiscent of the early novels, and we welcome a voice we haven't heard in years. The point of view is Scarpetta's, and this is her story.