Sega Mega Drive/Genesis: Ultimate Works features development and concept illustrations for Sega's best-loved game franchises, original developer interviews and previously unseen hardware production plans. Alongside the illustrated history is 'Arcade Perfect', a written history of the console and its legacy by Guardian Games Editor Keith Stuart, which features the voices of Sega executives and industry luminaries - including the company's founder David Rosen, its president Hayao Nakayama, Sega of America CEO Tom Kalinske and many more. The book opens with a foreword by legendary developer David Perry, on the console that catalysed his career.

Concluding the book are 28 specially-conducted interviews with original Sega developers and team members, including Naoto Ohshima (Sonic The Hedgehog), Yu Suzuki (Space Harrier), Greg Johnson & Mark Voorsanger (ToeJam & Earl), Makoto Uchida (Golden Axe) and Yuji Naka (Sonic The Hedgehog).