This book evaluates the factors behind Mexico’s painful experience with the Covid-19 crisis, a country that ranked fifth in the world for the number of deaths caused by the virus. Through a series of vignettes, its authors point to pandemic politics as the culprit. With a focus on the nexus of global governance and government in the Mexican case, they underline the politicized nature of domestic, international, and transnational responses to the pandemic. The chapters analyse the multiple political dimensions that affected the ability of intergovernmental and governmental authorities to construct timely, effective, and equitable health security against the COVID virus, including symbolic politics, medical populism, global political economy, disease diplomacy, epistemic communities, and federalism. This volume builds an interdisciplinary analysis of the politics of pandemic governance bridging political science, international relations, public policy and public administration, and public health.