Cherokee is old. His joints ache. His nose can no longer distinguish between the scent of bacon and a clump of dirt. His eyes see only shadows. On the eve of his death, he lies in a cage in an animal hospital, with a needle in his forepaw, and reflects on his life and purpose of being a faithful companion to his beloved mistress and best friend, Alicia Baxter.

Alicia and Cherokee's friendship begins when Alicia wanders into a pet shop and finds herself drawn to the puppy prancing before the window with his food bowl in his mouth. From the moment Alicia brings him home, Cherokee becomes an integral part of her journey of self-discovery as she struggles with insecurities, a lack of identity, and an unimaginable loss. Even as Alicia makes a life-altering decision to start over in a place where she is forced to rely on herself, Cherokee's love and loyalty to her never waver.

Narrated in a voice filled with wisdom, humor, and astute awareness, The Seasons of Cherokee's Life tells the story of a dog's deep bond with his mistress as he walks beside her and watches her transform into the courageous and independent woman he has always believed her to be.