This textbook is an introduction to Systems and Theoretical/Computational Neuroscience, with a particular emphasis on cognition. It consists of three parts: Part I covers fundamental concepts and mathematical models in computational neuroscience, along with cutting-edge topics. Part II explores the building blocks of cognition, including working memory (how the brain maintains and manipulates information "online" without external input), decision making (how choices are made among multiple options under conditions of uncertainty and risk) and behavioral flexibility (how we direct attention and control actions). Part III is dedicated to frontier research, covering models of large-scale multi-regional brain systems, Computational Psychiatry and the interface with Artificial Intelligence. The author highlights the perspective of neural circuits as dynamical systems, and emphasizes a cross-level mechanistic understanding of the brain and mind, from genes and cell types to collective neural populations and behavior. Overall, this textbook provides an opportunity for readers to become well versed in this highly interdisciplinary field of the twenty-first century.
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