This fourth volume contains two treatises of biblical exposition.

The first treatise is A Godly and Learned Exposition upon the Whole Epistle of Jude . Finding the purpose of Jude's letter in verse 3, Perkins calls for all Christians to persevere in professing the gospel by taking heed of false teachers and deceivers, who seek to infiltrate the church. While many of his points of application reflect a context peculiar to the Elizabethan era, his insights into what it means to "contend for the faith" still prove applicable today.

The second treatise is A Godly and Learned Exposition or Commentary upon the Three First Chapters of Revelation , giving careful consideration of the seven letters to the seven churches of Asia. Perkins highlights the person of Christ and His significance to the church, focuses on what Christ approves and rebukes about the condition of the church, and emphasizes Christ's bounty and humanity's duty. Troubled by the prevalence of those who accept empty profession as conversion and dead formality as godliness, Perkins urges his audience to move beyond mere intellectual assent to heartfelt dedication to Christ.